1. Suppression of Candida Biofilms with Iodide Oral Rinse-2007

    Objective: The purpose of this experiment was to determine the inhibitory effectiveness of several Iocide Oral Rinse formulations (OR) in the metabolic activities of cells in Candida albicans biofilms as assessed by XTT assay.
    Methods: Candida albicans (ATCC# SC5314) was propagated, washed 3X by PBS and suspended to 1×106 cells/ml in RPMI. One-tenth ml aliquots of the cell suspension were seeded to wells of 96 well microtiter plates…

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  2. Increased Bioavailability of Miconazole with Epikeia-2006

    The purpose of this study was to evaluate a novel polymer-based topical vehicle to deliver miconazole to human skin. The current study compared the dermato-pharmacokinetic uptake/elimination profiles of miconazole nitrate in a cream vehicle and miconazole base in the novel polymer delivery vehicle. To account for the differences in weight between the base and nitrate forms of miconazole, the drug concentrations were 1.738% miconazole base in the polymer vehicle and 2% miconazole nitrate in the cream…

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  3. Epikeia Treatment for Contact Dermatitis-2006

    This study investigated a polymer-based skin barrier to prevent and treat irritant contact reactions. The product is an acetone and polymer-based skin coating technology that is applied to the skin as a liquid that rapidly dries (~15 – 30 seconds) to form a thin film…

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  4. Clinical Efficacy and Acceptability of Iocide Gel-2004

    Iocide® is a novel, iodine-based, topical microbicide developed for vaginal use. Current clinical studies are focused on safety and acceptability of a single application to prevent intrapartum transmission of group B streptococcus (GBS) from mother to baby. Current strategies for prevention of early-onset GBS sepsis in the neonate require screening at 35-36 weeks and antibiotic administration during labor…

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